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After gaps of two or more weeks, restarting at your previous dose can overwhelm a body that has partially de-adapted

How to taper off semaglutide for weight loss safely How to Taper Off Semaglutide Safely Key takeaways: Medically, you don't have to taper off semaglutide, but many experts recommend it when stopping the medication

try not to skip doses, especially early on

Currently, yes semaglutide has proven cardiovascular benefit from the SELECT trial (2023), which demonstrated significant reduction in major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in patients with obesity and established heart disease