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In addition, loss of glutathione peroxidase 4 (GPX4), a central regulator of ferroptosis, leads to hemolytic anemia and increases spleen erythroid progenitor death through receptor-interacting protein 3 (RIP3)-dependent necroptosis signaling 48

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the latter consists of AIN93G-CAS containing 45% of total kcal from lard fat, recapitulating the percent kcal from fat in a typical Western diet (Wilson et al., 2007)