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However, data directly comparing GLP-1RA and SGLT-2 inhibitors are lacking, which limit the choice of clinicians between them

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For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]

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This virtual structure helps make the powerful, FDA-approved medications like Wegovy and Zepbound more available to a wider population