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Role: Fructose-6-P Fructose-1,6-bisphosphate Regulation: Activated by AMP, fructose-2,6-bisphosphate (F2,6-BP) Inhibited by ATP, citrate They love the hormonal angle: insulin vs glucagon through PFK-2/FBPase-2 controlling F2,6-BP levels

It also replaces GLP-1s most vulnerable amino acid, alanine, with one less easily broken down

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Your healthcare provider considers your treatment goals, current health status, medication tolerance, and response to therapy when establishing and adjusting your dosing regimen