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Nitric oxide causes vasodilation the widening of blood vessels which increases blood flow to working muscles, improves oxygen delivery, reduces lactic acid buildup, and extends endurance capacity

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To increase accumulation in the posterior segment after topical administration, we previously developed a novel hypotonic in situ gel-forming eye drop formulation [20]

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Furthermore, oxidative stress activates the release of HMGB1 signal transduction in keratinocytes by decreasing the level of melanogenetic molecules (including gp100) and inducing apoptosis