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BBB dysfunction results in reduced cerebral blood flow, impaired nutrient delivery, and the accumulation of neurotoxic substances, all of which contribute to neurodegeneration

The injectable delivery of GLP-1 drugs shows rapid onset of action and bioavailability

Also, noticing that constipation showed up in week three and hasn't improved since shows a trend that might not be noticed until it gets uncomfortable enough to need attention

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The safety profile of semaglutide is generally favorable, though some common side effects include nausea, vomiting, diarrhea, and constipation