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A temporal metabolomics study revealed that before PINK1/Parkin-mediated mitophagy reached its peak, lipid metabolism events (e.g., accumulation of triglyceride) occurred and lipid homeostasis was altered in mammalian cells ( Taken together, these interacting mechanisms constitute a complex regulatory network, and in-depth studies of the balance between mitophagy and biological processes such as OS, inflammation, MFB activation, apoptosis, and energy metabolism will help to shed light on the pathogenesis of fibrotic diseases and provide new insights for the development of more effective therapeutic strategies

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