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650 and spread to Arabia then Europe Classified as a drug and banned in many cultures Cocoa: Mayan and Aztec royalty Only small amount of caffeine in cocoa Miscellaneous Plant Stimulants Pharmacology Classified as an akaloid of the chemical class called xanthines Found in more than 60 plants Takes 15-35 hours for 95% of the caffeine to be excrete by the body Physical and Mental Effects Mild stimulant 5-7 cups of coffee can cause anxiety, insomnia, nervousness Higher doses can cause muscle twitching, increased heart rate, palpatations Letal at about 10 grams (100 cups of coffee) Miscellaneous Plant Stimulants Tolerance, withdrawal & addiction Dosages vary depending on person Symptom includes throbbing headache Dependence can occur with 5 cups of coffee 10 cola drinks or 8 cups of tea Nicotine Cigarettes account for 90% of all tobacco use in U.S

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