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However, in addition to the pathophysiological development of critical illness caused by the effects of the primary disease, it is undeniable that extracorporeal circulation itself induces an inflammatory response, which further intensifies the systemic inflammatory response and leads to a systemic storm of inflammatory factors, further developing into the adverse outcome of multi-organ failure

However, for the vast majority of foundational research where precise, controlled systemic delivery is paramount, the syringe remains the essential tool