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Recognizing the separate potentials, the Arizona team split the projects: Melanotan I was licensed off for tanning use, and Melanotan II was licensed to Palatin Technologies to develop for sexual dysfunction

5 Once steady state is reached, the washout period for AJOVY is similar for monthly and quarterly dosing (~5-6 half-lives) 6 Washout period defined as time until plasma concentrations of AJOVY are below a clinically relevant concentration and thus considered eliminated

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Researchers first identified it during sleep experiments in the 1970s after isolating it from brain-related tissue and blood in animals and humans