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This is because "58 percent of patients discontinue use before reaching a clinically meaningful health benefit," the research carried out by the Blue Cross Blue Shield Association (BCBSA) and conducted by Blue Health Intelligence concluded

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Aging and oxidative stress reduce the response of human articular chondrocytes to insulin-like growth factor 1 and osteogenic protein 1

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Those likely to obtain benefit from berberine include people with metabolic disorders including PCOS, insulin resistance and type 2 diabetes as well as those with mildly high cholesterol