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A small case-controlled study comparing 52 DS cases to 52 control cases noted that average maternal serum homocysteine concentration was slightly higher in mothers giving birth to children with DS but this difference was not statistically significant (Mohanty et al 2012)

The signal transduction pathways activated by CaSR lead to inactivation of the transporters NKCC2 (encoded by the SLC12A1 gene), ROMK (encoded by the KCNJ1 gene) and Na + /K + -ATPase resulting in decreased reabsorption of Ca 2+ and Mg 2+

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GLP-1 receptor agonists (semaglutide, liraglutide) are MHRA-approved medications that lower blood glucose and promote weight loss by mimicking a natural hormone