When appetite is suppressed, calorie intake drops
With support, adjustments, or new strategies, people often find ways to reconnect with intimacy
So they may lose weight initially, but then they plateau, feel worse, or regain the weight when they stop." Another issue is that GLP-1 medications can cause muscle loss and a drop in metabolic rate, which may make long-term weight maintenance more difficult
The second most common is step therapy failure, meaning you have not tried enough lower-cost medications first
The predominant side effects include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (affecting 10-50% of patients depending on the specific product and dose, particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the subcutaneous injection site Hypoglycaemia : particularly when combined with insulin or sulphonylureas Decreased appetite : an intended therapeutic effect that contributes to weight loss However, some patients do report changes in urinary frequency or patterns
