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For example, in a recent study, menopausal women with obesity or overweight lost more weight when tirzepatide was used along with HRT, and they had better cardiometabolic outcomes

Diabetes Obes Metab 2022;24:13609 26

Around a quarter (26%) of people diagnosed with heart disease have used GLP-1 medications, and 22% of people diagnosed as being overweight or obese say they have used them or are currently using them

This effect was further verified in human studies

According to the MHRA's latest guidance, while occurrences are rare, there have been reports of severe, necrotizing, and even fatal pancreatitis associated with GLP-1 and GIP receptor agonists