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This action removes two fibrinopeptides, exposing knobs and holes, and leading to a remarkable self-assembly in which fibrin monomers polymerise to make staggered oligomers, which themselves lengthen into protofibrils that aggregate laterally to make fibres, finally branching to create a three-dimensional network which represents the clots

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The release notes that these results are consistent with third-party test results previously reported in an earlier company news release, confirming that the commercial production run has maintained the quality parameters established during earlier formulation validation work

doi: 10.1111/jocd.15763