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2.2.1 TGF- TGF- is the most potent pro-fibrotic mediator, inducing ECM, EMT, and pro-fibrotic mediators production by promoting the binding of Smad2/3 to Smad4, and driving myofibroblast differentiation to promote the PF process (Hu et al., 2018

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Researchers found that melanotan I could reduce the severity of PLE related pruritus when administered as 16 mg implants over a period of 4 months [14]