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Consistently, we found that administration of CA, an endogenous FXR agonist, could not only significantly attenuate the T3-induced elevation of GLP-1 and insulin levels but also attenuate the glucose-lowering effect of T3 in MMI mice (Fig

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This indicates that its not a general access across the bloodbrain barrier we have here with our GLP-1 receptor agonist but rather a specialized uptake, likely around circumventricular organs. She concluded with the following key takeaways: Both GLP-1 and acylated GLP-1 analogs have access to discrete brain regions

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