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Oral GLP-1 launches and stronger-than-expected persistence could accelerate the timeline slightly

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Application of hepatocyte growth factor for amyotrophic lateral sclerosis

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As mentioned in the section above, IDH1 catalyzes typically the conversion of isocitrate to -KG, but the mutant isoform converts -KG into D-2HG instead, which has been shown to inhibit cellular differentiation through epigenetic alterations [19]