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( a ) Serum acetoacetate (AcAc) and BHB levels across two independent cohorts comprising 289 patients with colorectal adenomas and carcinomas, including a test cohort (n = 100) and a validation cohort (n = 189)

big data from omics technologies), computer-aided drug design (including artificial intelligence, AI) is now routinely employed to facilitate the discovery and design of promising candidate compounds [241,242,243,244,245,246]

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