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tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles

[1] [2] Whether this contributes to sleep difficulties in humans is not established

Many GLP-1 users are already tired of tracking across separate apps, spreadsheets, and notes

Sex differences in odds of brain metastasis and outcomes by brain metastasis status after advanced melanoma diagnosis

There are also many disabilities and medical conditions causally associated with alcohol, with more prevalent conditions (such as cardiovascular diseases, liver disorders, malignancies, and other related conditions) contributing to a significant amount of alcohol-associated morbidity [4]