Traditional treatments (topical steroids, biologics, immunosuppressants) target these pathways directly
Alternatively, STING may be degraded through selective macroautophagy, whereby TBK1-mediated phosphorylation of p62 at S403 increases its affinity for K63-ubiquitinated STING (168) and ubiquitously expressed transcript (UXT) may facilitate the interaction between p62 and STING (169)
PubMed, Santos, Beatriz Werneck Lopes, et al
Anecdotally, benzyl alcohol also has a mild local anesthetic effect
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