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retatrutide carries GLP-1 class risks including nausea, gallbladder disease, pancreatitis, and delayed gastric emptying affecting oral medicine absorption

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The MHRA has licensed several GLP-1 agonists for use in the UK, and NICE guidelines (NG28) recommend them for specific patient groups, particularly those with type 2 diabetes who have not achieved adequate control with other medications or who have additional cardiovascular risk factors