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In vitro, human corneal epithelial cells underwent scratch-wound assays and cytokine profiling

While laboratory studies provide insights into peptide activity, these observations remain under investigation and should not be interpreted as confirmed therapeutic effects

Chromatography was carried out on a Luna C18(2) column (Phenomenex

Figure 1 3.2.1 Glycated hemoglobin It has been documented that serum glycated hemoglobin (HbA1c) levels are significantly higher in individuals with DCM in comparison to those with T2DM alone ( 3.2.2 Cardiac troponin I Observational studies ( 3.2.3 Natriuretic peptides Natriuretic peptides including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were proposed as potential biomarkers of DCM before ( 3.2.4 O-linked N-acetylglucosamine Increased O-linked N-acetylglucosamine (O-GlcNAc) levels were previously linked to the adverse cardiac effects of T2DM, including impaired contractility, calcium handling and abnormal stress response ( 3.2.5 Inflammatory, fibrotic and antioxidant markers Serum inflammatory mediators such as TNF-, interleukins and C-reactive protein (CRP), elevated fibrotic markers like TGF- and insulin-like growth factor binding protein-7 (IGFBP-7) and decreased antioxidant markers adiponectin and leptin are suggested to uncover early onset of DCM ( Several other novel markers for DCM have been proposed by recent studies, including galectin-3 (Gal-3) and adiponectin ( Adiponectin is a member of adipokines that affect insulin sensitivity and hyperadiponectinemia is considered an independent risk factor for DCM ( 3.2.6 Noncoding RNAs New evidence also suggests several microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as biomarkers of DCM ( 3.2.7 Metabolic markers Some plasma biomarkers of abnormal metabolism have been recently identified using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics ( 4 Current therapeutic approaches to mitigate the symptoms of diabetic cardiomyopathy To this date, there is no specific therapy for DCM