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doi: 10.1016/j.heliyon.2021.e07064 22 XuegangNQiYKaijianHYuTPenghuiWYangZet al

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Verify monoisotopic mass and detect oxidation peaks (Met +16 Da for Semax) or truncation

The combination of GPX4 and CDK4/6 inhibitors is more effective than the single drugs in ER+ and triple negative breast cancer models To further evaluate the potential of targeting GPX4 to enhance CDK4/6 inhibitor sensitivity, we investigated the effect of combining GPX4 inhibitors with palbociclib in a panel of ER+ and RB1 wild type TNBC cell lines